ARRABIDAEA CHICA PDF

Arrabidaea chica Bignoniaceae is a vine native to the Amazon Rainforest, popularly known as "crajiru" in Brazil and "puca panga" in Peru. In the Amazon where it grows, an infusion or decoction of the leaves are used to treat diseases such as gastric ulcers, inflammations, infections, anemia, herpes, and jaundice among others. The Tropical Plant Database. Share This Page.

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The aim of this study was to analyze the analgesic potential of Arrabidaea chica extract EHA as an alternative to osteoarthritis OA treatment. Thus, the extract was initially evaluated by the cyclooxygenase inhibition test.

The analgesic effect of the extract, in vivo, was also verified in a model of OA induced by sodium monoiodoacetate 2 mg. The animals were clinically evaluated every 7 days, euthanized at 29 days, and the liver, spleen, kidney and knee collected for histopathological analysis.

The results showed that the extract promoted cyclooxygenase inhibition and produced significant improvements in disability, motor activity, hyperalgesia, and OA-induced allodynia parameters, in addition to improvements in the radiological condition of the knees but not observed in the histopathological study. Chemically the extract is rich in flavonoids. Among them, we evidence that amentoflavone showed very favorable interactions with the enzyme COX-2 in the in silico analysis.

Thus, it is concluded that A. Keywords: antinociception; bioinformatics; inflammation; molecular docking; pain; pariri; phytotherapy; plants. The authors declare no conflict of interest and that the funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Effects of A. Sections of articular cartilage with different grades of degenerative changes in osteoarthritis OA …. This site needs JavaScript to work properly.

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Full-text links Cite Favorites. Abstract The aim of this study was to analyze the analgesic potential of Arrabidaea chica extract EHA as an alternative to osteoarthritis OA treatment. Conflict of interest statement The authors declare no conflict of interest and that the funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures Figure 1 5 Percent inhibition of in vitro…. Figure 2 5 Effects of the A. Figure 2 13 Effects of the A. Effects of the A. After 7, 14, 21, and 28 days of induction, the motor activity of the animals was measured to evaluate the rotarod score. Figure 3 5 Effects of the extract A. Figure 3 13 Effects of the extract A. Effects of the extract A. The induction of osteoarthritis was done by the injection of MIA 2 mg in the knee of Wistar rats. After 7, 14, 21, and 28 days of induction, the weight distribution on the hind legs of the animals was measured for the assessment of the incapacity by means of the Weight Bearing test.

Figure 4 5 Effects of A. Figure 4 13 Effects of A. After 7, 14, 21, and 28 days of OA induction, the nociceptive threshold of withdrawal of the affected paw was measured by indirect evaluation with Randall Sellito apparatus. Figure 5 5 Effects of A. Figure 5 13 Effects of A. After 7, 14, 21, and 28 days of OA induction, mechanical allodynia was measured by indirect evaluation with the von Frey test.

Figure 6 5 Degree of joint involvement in…. Figure 6 13 Degree of joint involvement in rats treated with A. Degree of joint involvement in rats treated with A. This analysis was performed with the knees collected on day 29 after OA induction.

The data are represented according to classification proposed by Kellgren—Lawrence. Figure 7 5 Knee radiographs in the antero-posterior…. Figure 7 13 Knee radiographs in the antero-posterior projection. A -RX from the healthy rat paw…. Knee radiographs in the antero-posterior projection. Arrowhead: red—indicating a remarkable narrowing of the joint space and deformity in the bone contour; green—subchondral sclerosis; orange—large osteophytes.

Figure 8 5 Histopathological evaluation of cartilage classified…. Y -axis: Histopathological evaluation of cartilage OARSI histological classification: Grade 0—surface intact and cartilage intact; Grade 1—surface intact; Grade 2—surface discontinuity; Grade 3—vertical fissures; Grade 4—erosion; Grade 5—denudation; and Grade 6—deformation.

Figure 9 5 Sections of articular cartilage with…. Figure 9 13 Sections of articular cartilage with different grades of degenerative changes in osteoarthritis OA …. B Example of CTL-group treated with 0. B, C, and D with degrees on average between 5. Green arrow indicates normal cartilage lining intact surface and cartilage ; blue arrow indicates microfractures; red arrow indicates erosion with bone expositon; red circles indicate repair fabric; yellow arrowindicates complete erosion; yellow circles indicate fibrocartilage formation and bone remodeling.

Figure 10 5 Exemplary histological sections of the…. Figure 10 13 Exemplary histological sections of the liver A , kidneys B ,…. Figure 11 5 Chromatogram of total ions obtained…. Figure 12 5 2D representation of the interactions…. Dashed lines represent hydrogen bonds; green lines represent van der Waals interactions.

Figure 13 5 Experimental design. Figure 13 13 Experimental design. All figures See this image and copyright information in PMC. Similar articles Arrabidaea chica extract improves gait recovery and changes collagen content during healing of the Achilles tendon. Aro AA, et al. Epub Oct 7. PMID: Chitosan-tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity.

Servat-Medina L, et al. Int J Nanomedicine. Gemelli TF, et al. J Toxicol Environ Health A. Epub Sep Evaluation of wound healing properties of Arrabidaea chica Verlot extract. Jorge MP, et al. J Ethnopharmacol. Epub May 4. Chenopodium ambrosioides L.

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Evaluation of Safety of Arrabidaea Chica Verlot (Bignoniaceae), a Plant With Healing Properties

The leaves are source of chica dye. From Wikipedia, the free encyclopedia. Lohmann — The Plant List". Retrieved Taxon identifiers. Hidden categories: Articles with 'species' microformats Commons category link is on Wikidata Taxonbars with automatically added basionyms All stub articles.

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The aim of this study was to analyze the analgesic potential of Arrabidaea chica extract EHA as an alternative to osteoarthritis OA treatment. Thus, the extract was initially evaluated by the cyclooxygenase inhibition test. The analgesic effect of the extract, in vivo, was also verified in a model of OA induced by sodium monoiodoacetate 2 mg. The animals were clinically evaluated every 7 days, euthanized at 29 days, and the liver, spleen, kidney and knee collected for histopathological analysis. The results showed that the extract promoted cyclooxygenase inhibition and produced significant improvements in disability, motor activity, hyperalgesia, and OA-induced allodynia parameters, in addition to improvements in the radiological condition of the knees but not observed in the histopathological study. Chemically the extract is rich in flavonoids.

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Currently available leishmaniasis treatments are limited due to severe side effects. Arrabidaea chica is a medicinal plant used in Brazil against several diseases. In this study, we investigated the effects of 5 fractions obtained from the crude hexanic extract of A. Promastigotes were treated with several concentrations of the fractions obtained from A. To evaluate the inhibitory activity of B2 fraction on Leishmania peptidases, parasites lysates were treated with the inhibitory and subinhibitory concentrations of the B2 fraction.

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