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Biochimie métabolique et structurale
The word fat has an almost universally negative connotation in modern society, whether as a pejorative term for describing someone who is overweight or as a foodstuff reviled for its deleterious impact on health. Now, however, Yore et al. Furthermore, they show that administering these fatty acids to such mice improves glucose uptake from the blood, enhances insulin secretion and relieves obesity-associated inflammation, suggesting that these naturally occurring fats could be used for diabetes therapy. Fatty acids and closely related glycerolipid molecules wear multiple biological hats, serving as a major energy reservoir, as constituents of cell membranes and as mediators of intracellular signalling. Yore and colleagues' report adds to emerging evidence implicating specific, low-abundance fatty acids as hormone-like 'lipokine' molecules involved in metabolic regulation. The same research group had previously shown that elimination of the glucose-transport protein GLUT-4 from adipose fat-storing tissue resulted in insulin resistance in liver and muscle — a condition in which cells of these organs have an impaired capacity to increase glucose uptake in response to insulin, contributing to the abnormally high blood-glucose levels that define diabetes.
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