CONNECTING MTORC1 SIGNALING TO SREBP 1 ACTIVATION PDF

Over the past years, several studies revealed that mTORC1 also plays a crucial role in promoting lipid biosynthesis and that such connection could be linked to diseases including obesity, nonalcoholic fatty liver disease NAFLD , and cancer. Here, we review the mechanisms by which mTORC1 regulates lipid synthesis by focusing on the key signaling events that trigger hepatic de-novo lipogenesis in response to nutrients and insulin. A better comprehension of these mechanisms is key for the development of new tools to treat NAFLD and its complications. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

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Over the past years, several studies revealed that mTORC1 also plays a crucial role in promoting lipid biosynthesis and that such connection could be linked to diseases including obesity, nonalcoholic fatty liver disease NAFLD , and cancer. Here, we review the mechanisms by which mTORC1 regulates lipid synthesis by focusing on the key signaling events that trigger hepatic de-novo lipogenesis in response to nutrients and insulin.

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Metabolism: Clinical and Experimental. Marshall B Elam Rajendra Raghow. Rag proteins regulate amino-acid-induced mTORC1 signalling opens in new tab. Biochemical Society Transactions. Yasemin Sancak , David M Sabatini. Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected opens in new tab. Bangyan Stiles Hong Wu. Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver opens in new tab.

Guoxun Chen M S Brown. Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling opens in new tab. Yonghao Yu John Blenis. See more references from this paper Sign Up. Proinflammatory and antiinflammatory attributes of fetuin-a: a novel hepatokine modulating cardiovascular and glycemic outcomes in metabolic syndrome opens in new tab. Satinath Mukhopadhyay Deep Dutta.

Nuclear reprogramming of luminal-like breast cancer cells generates Sox2-overexpressing cancer stem-like cellular states harboring transcriptional activation of the mTOR pathway opens in new tab.

Cell Cycle. Acne vulgaris opens in new tab. Nature Reviews. Disease Primers. Circulation Research. Franziska Pankratz Sebastian Grundmann. International Journal of Molecular Sciences. Adrian P Duval Olivier Dormond. See more citations of this paper Sign Up. Mentioned in this Paper. Sterol Regulatory Element Binding Protein 1. Protein kinase B gamma. FRAP1 protein, human. Protein Biosynthesis. Non-alcoholic Fatty Liver Disease.

Sterol Regulatory Element Binding Protein 1c. Response to Nutrient. About this Paper. PMID: DOI: Trending Feeds. Synthetic Genetic Array Analysis Synthetic genetic arrays allow the systematic examination of genetic interactions.

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Over the past years, several studies revealed that mTORC1 also plays a crucial role in promoting lipid biosynthesis and that such connection could be linked to diseases including obesity, nonalcoholic fatty liver disease NAFLD , and cancer. Here, we review the mechanisms by which mTORC1 regulates lipid synthesis by focusing on the key signaling events that trigger hepatic de-novo lipogenesis in response to nutrients and insulin. Continue Reading. Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease COVID; formally known as nCoV. Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

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Connecting mTORC1 signaling to SREBP-1 activation.

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