Fibromuscular dysplasia FMD is a condition that causes extra cells to grow inside the walls of arteries. Arteries are blood vessels that carry blood from your heart to the rest of your body. The extra cell growth narrows the arteries, allowing less blood to flow through them. It can also lead to bulges aneurysms and tears dissections in the arteries. FMD affects between 1 percent and 5 percent of Americans. About one-third of people with this condition have it in more than one artery.
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Fibromuscular dysplasia includes a heterogenous group of nonatherosclerotic, noninflammatory arterial changes, causing some degree of vascular stenosis, occlusion, or aneurysm.
Fibromuscular dysplasia usually occurs in women aged 40 to The cause is unknown. However, there may be a genetic component, and smoking may be a risk factor. Fibromuscular dysplasia is more common among people with certain connective tissue disorders eg, Ehlers-Danlos syndrome type 4, cystic medial necrosis, hereditary nephritis , neurofibromatosis. Medial dysplasia, the most common type, is characterized by alternating regions of thick and thin fibromuscular ridges containing collagen along the media.
In perimedial dysplasia, extensive collagen deposition occurs in the outer half of the media. Fibromuscular dysplasia is usually asymptomatic regardless of location. Symptoms, when they occur, vary by location:. Claudication in the thighs and calves, femoral bruits, and decreased femoral pulses when leg arteries are affected.
Secondary hypertension when renal arteries are affected. Transient ischemic attack or stroke symptoms when carotid arteries are affected. Rarely, mesenteric ischemic symptoms when intra-abdominal arteries are affected. Ultrasonography may suggest the diagnosis, but definitive diagnosis of fibromuscular dysplasia is made by angiography showing a beaded appearance in medial or perimedial dysplasia or a concentric band or long, smooth narrowing in other forms.
Treatment of fibromuscular dysplasia varies by location. It may involve percutaneous transluminal angioplasty alone, percutaneous stent angioplasty, bypass surgery, or aneurysm repair. Smoking cessation is important. Control of other risk factors for atherosclerosis hypertension , dyslipidemia , diabetes helps prevent accelerated development of flow-limiting arterial stenoses.
Patients who have connective tissue disease, who smoke, or who have a family history are at higher risk. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world.
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Common Health Topics. Videos Figures Images Quizzes. Key Points. Peripheral Arterial Disorders. Test your knowledge. Which of the following is a sign or symptom of right ventricular failure in heart failure? More Content. Fibromuscular Dysplasia By Koon K. Click here for Patient Education. Fibromuscular dysplasia is most common in women age 40 to 60 years. Treatment depends on the location and includes angioplasty, bypass surgery, or aneurysm repair.
Was This Page Helpful? Yes No. Peripheral Arterial Aneurysms. Renovascular Hypertension. Renal Artery Stenosis and Occlusion. Abdominal Aortic Branch Occlusion. Mitral Regurgitation. Doppler echocardiogram, parasternal long-axis view. By convention, flow toward the transducer Cardiac Conduction System. Add to Any Platform.
A envergadura pode ultrapassar a altura. Podem ocorrer deformidades do peito, escoliose ou cifose da coluna. Fibromuscular dysplasia: an uncommon cause of secondary hypertension. J Clin Hypertens ;8 12 Systemic fibromuscular dysplasia masquerading as polyarteritis nodosa.
Fibromuscular dysplasia: unusual cause of abdominal pain. Displasia fibromuscular: causa infrecuente de dolor abdominal. Rebolledo and C. Spontaneous dissection of the renal artery is a rare phenomenon, and is more common amongst men. It is not a frequent cause of abdominal pain 2 , which is why diagnosis is often late.
The prevalence is unknown 7. It is most common in young women with a female to male ratio of , and is typically diagnosed between the ages of 30 and 50 4. The exact cause is not well known. The underlying pathology is fibrous or fibromuscular thickening of the arterial wall. Any layer of the vessel wall may be affected: intima, media or adventitia. There is absence of inflammatory cells ,7.
Fibromuscular dysplasia includes a heterogenous group of nonatherosclerotic, noninflammatory arterial changes, causing some degree of vascular stenosis, occlusion, or aneurysm. Fibromuscular dysplasia usually occurs in women aged 40 to The cause is unknown. However, there may be a genetic component, and smoking may be a risk factor.